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You're listening to Shortwave from NPR. Hey, short wavers.
I love my job, but I'm going to be honest, sometimes it's stressful.
And when I'm stressed, I can definitely feel it in my body, which science journalist Diana Kwan says makes sense.
I've reported a lot of stories in the past about the biological effects of stress.
Stress can really take a physical toll, but I don't think I realized just how much of a toll until this episode, when I called her to discuss the link between stress and aging.
And she told me, yep, Gina, there's a whole body of research on this very topic.
It just kind of made a lot of sense that stress would affect aging as well because, you know, things like various disorders and diseases, you know, these all affect how quickly we age.
She told me about a study researchers did in the early 2000s looking at stress in 58 biological mothers.
About a third or a bit more than a third who had a healthy child and two-thirds who had a child with a chronic illness.
And they kind of reasoned that this latter group... would have higher levels of stress due to having to take care of somebody with an illness.
Part of the study included asking those parents about their stress levels, which were higher for the caretakers of kids with an illness.
But Diana says this study also did something pretty unique.
It was one of the first studies to really bring the stress and aging link to like the molecular level.
So more researchers started looking for signs of psychological stress in people's DNA.
You know, not only did this group of people with a chronically ill child report having higher levels of stress, they also had shorter telomeres.
Telomeres are the protective caps on the ends of chromosomes, and overall their shortening is associated with aging.
So more stressed parents with shorter telomeres equals biologically older parents.
Since then, other studies have found other clues to how stress affects the body on the molecular level.
They linked chronic stress to an increase in something called senescent, or zombie cells.
As our cells age, they stop performing their regular functions and they enter this kind of sleepy zombie-like state.
And they stop dividing, like normal cells do.
Some researchers are starting to think that these zombie cells are sucking up resources from the rest of our body, which ultimately results in aging.
And could ultimately help researchers answer the question, what is it about stress that's changing our cells that, you know, makes people become less healthy later in life?
Today on the show, a new hypothesis for how the brain handles these aging zombie-like cells may help researchers understand aging on the molecular level, plus what science could do about it.
I'm Regina Barber, and you're listening to Shortwave, the science podcast from NPR.
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Okay, Diana. So these researchers that are studying aging, they've developed this hypothesis called the brain-body energy conservation model.
As a physicist, I love any energy conservation model, actually.
How does this work? Yeah, yeah. So this is a really interesting model developed by a small group of aging researchers.
So it's by no means a well-established, widely accepted model yet.
But basically, as our cells get older, they accumulate... energetically costly forms of damage.
So these are things like becoming zombie-like or senescent or accumulating DNA damage or inflammation.
You know, all of these things are... Those telomeres shortening.
Exactly. So all of these things require energy to fix.
And so the brain through, you know, various signaling molecules that... are coming through the body senses that, okay, there's a bunch of cells out there that need energy.
And so we're going to take energy away from other processes to fuel this damage control.
And so this ultimately results in the outward signs of aging that we're all familiar with, things like graying hair or reduction in muscle mass that are less essential than keeping ourselves alive.
Yeah, it makes me think of like how older appliances like fridges, you know, like use more energy.
They're less energy efficient like than the newer ones that are like running well, you know?
Yeah. So in your piece, you write about an experiment these researchers did, the ones who came up with this model, a couple years back to look at how these zombie cells use energy.
Can you tell me more about that? Yeah, so...
This was back in, I think, 2022, where a bunch of researchers at Columbia took human skin cells and cultured them in a laboratory dish.
And they observed them over a short period of time, and they found that the cells that had stopped dividing and entered this zombie-like state disappeared. were using about double the energy that younger cells were.
And this kind of flew in the face of what researchers had thought about these zombie cells because a lot of people thought, okay, a cell doesn't divide anymore.
Cell division requires a lot of energy. These cells must not need a lot of energy.
But actually, it turns out that they're burning a lot of energy.
And so the researchers went and kind of looked at the literature and found, oh, wait, there's, like, all of these other damage processes that are happening, and these are all costly.
You know, we should put this into a model, and, you know, the brain-body energy conservation model is what they came up with.
And this is a pretty new hypothesis, right?
Like, the entire aging research community isn't completely convinced yet, right?
Yeah, it's absolutely a new hypothesis. They only came up with it, you know, in the last couple of years, and...
The researchers I spoke to who hadn't developed this hypothesis, a lot of people thought it was really intriguing.
And I think what a lot of people like about it is that it kind of brings the brain and body together in aging.
And that's something that hasn't really been done before, this kind of unified hypothesis of aging.
One can kind of think of it in that way.
But in a lot of ways, a lot of pieces of this puzzle are untested, even though there are some really... compelling hints or pieces of evidence that this might actually be happening.
Right. Yet one of these things that has come up in these studies is this molecule called GDF-15.
Why is this important in this research? Yeah.
So GDF-15 or growth differentiation factor 15, which is a bit of a mouthful.
So I think this was one of the most fascinating pieces of the brain-body aging model puzzle.
So basically GDF-15 is a cellular messenger.
And Researchers think it might play a really central role in mediating the link between the body and brain in aging.
And this molecule has also come up in aging research, sort of not related to the brain either.
So it's been linked to a bunch of different aging-related processes.
Once again, cellular senescence or a zombie-like state.
So, you know, this molecule is found to be linked to that process.
Also a dysfunction in mitochondria or the cellular powerhouses.
This is also something that happens as we age.
GDF-15 is also linked to aging-related diseases like Alzheimer's and a bunch of chronic physical and mental illnesses too.
And so one thing that's really interesting about this molecule is that it's secreted by many, if not all, of our organs, but the receptor for this molecule is only found in one place in the body, and that's in the brain.
And so, you know, all of these things together, yeah, have made researchers think, okay, maybe GDF-15 is responsible for sending the brain signals about cellular stress.
So this is kind of a working hypothesis at the moment, but a really fascinating molecule that might play a really important role or be a really important piece of this whole puzzle.
There's so many unknowns still, but scientists are already trying to create medicines like to slow down aging.
So with this new hypothesis, how are scientists going to maybe think differently about clinical trials?
Yeah, I think both of this new hypothesis and the kind of growing body of research that shows that stress plays a really important role in these aging-related processes.
What a lot of the stress researchers or the stress and aging researchers that I spoke to said is that, you know, this field of aging, which traditionally hasn't really thought about the effects of stress, should really think about aging. how much stress the people who are taking these drugs or, you know, will be taking these drugs in the future are exposed to because that might have a huge impact on how well these interventions work.
When you were doing this story at the very end, when you've done all this reporting, did you come away thinking differently about aging, about stress?
I guess yes and no. No in that, you know, I wasn't necessarily surprised that stress, which affects so many parts of our body, affects aging as well.
But I guess yes in that for such a long time, it was kind of this like woo-woo connection.
Oh, you know, stress causes aging, but how without a mechanism?
So I thought it was really cool that this research seems to be entering a kind of new era where, you know, hopefully it'll start to make a big difference in people's lives.
Yeah, I mean, this actually does make me feel like more hopeful as well about stress and aging.
Yeah, absolutely. And that makes me think of, you know, there's actually been some experiments where scientists have found that some of these stress-related aging changes in our cells are reversible.
So there were researchers who did a study in monkeys where they found that monkeys that were stressed out had these changes in their immune cells that were linked to accelerated aging.
But they found that when they switched up their conditions and put them in less stressful situations, you know, all of a sudden the cells bore less or reduced signs of accelerated aging.
So I think that's a really positive thing because I think this kind of stress may... be linked to aging or cause aging at some level, it can be a really negative message and it can stress people out to think that stress is going to age you because, you know, stress is one of these things.
You're stressed because you're stressed about stress.
Exactly. But, you know, these changes are not irreversible.
These are things that, you know, we can affect in our daily lives to some extent.
It's kind of more hopeful in my view. It's a hopeful view of the future where we will have a toolbox of things that may help us stay healthy for longer.
Yeah. And less stressed. Yeah. Diana, thank you so much for talking to me today about aging.
It makes me think about aging, you know, more because I always think about it.
Don't we all? Thanks so much for having me.
Short Wavers, thank you for listening. If you want to help us out, share this episode with a friend.
We want to grow as we age and reach even more science-curious people.
And that's one of the best ways to do it, by word of mouth, from you to your friends.
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This episode was produced by Burleigh McCoy, edited by a showrunner, Rebecca Ramirez, and fact-checked by Tyler Jones.
The audio engineer was Jimmy Keeley. Beth Donovan is our senior director and Colin Campbell is our senior vice president of podcasting strategy.
I'm Regina Barber. Thank you for listening to Shorewave from NPR.
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We're getting into the nitty gritty of what government does with things like trade, taxes, immigration, and healthcare.
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