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[The Science of Pain: Why Some Creatures Are Immune to Wasabi]-[G-Force Vs. Wasabi: How The Brain Registers Pain (encore)]

Wow in the World · B1 · 2021-03-22

Preschool Enlightenment
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📋 Summary

The Science of Pain: Why Some Creatures Are Immune to Wasabi

In this episode of Wow in the World, hosts Mindy and Guy Raz embark on a hilarious, high-stakes adventure at the "13th Annual Hot Pickle and Pepper Championships." While the event serves as a platform for intense competition, it provides a unique scientific lens through which to examine how different species process pain and chemical irritation.

The Chemistry of Heat: Capsaicin vs. Wasabi

The competition highlights the distinction between two common culinary irritants. First, there is capsaicin, the natural chemical found in hot peppers that creates a burning sensation. The heat of these peppers is measured on the Scoville heat unit scale, with competition peppers reaching up to 2 million units. Mindy and Guy Raz explain that our perception of this heat is mediated by neurons—tiny cells in the brain that transmit pain signals from the body. Some creatures, like the Naked Mole Rat, have evolved to lack the specific neurons that register capsaicin as painful, allowing them to consume incredibly spicy peppers without discomfort.

However, the competition takes a turn when the hosts introduce wasabi. Unlike peppers, wasabi relies on a different chemical compound called allyl isothiocyanate (AITC). While capsaicin burns the tongue, AITC typically affects the sinuses and nasal passages, creating a sensation that can make one's head feel like it is going to explode.

The Highveld Mole Rat's Evolutionary Edge

The climax of the episode occurs when an unexpected contestant, Harold the Highveld Mole Rat, outperforms both the reigning champion, Grandma G-Force, and the Naked Mole Rat by consuming a spoonful of wasabi with zero reaction. This leads to a fascinating discussion regarding research conducted by Dr. Gary Lewin at the Max Delbrück Center in Berlin.

Dr. Lewin’s research suggests that Highveld Mole Rats possess a biological "escape hatch" in their neurons. This mechanism allows AITC chemicals to leak out or escape before they can trigger a pain response in the brain. Scientists theorize that this is an evolutionary adaptation developed over millions of years. Highveld Mole Rats share their underground habitats with natal drop tails—ants that possess a sting containing a chemical very similar to AITC. To survive, the mole rats evolved to become resistant to this specific type of chemical pain.

Scientific Implications for Humans

Beyond the humor of a mole rat winning a spicy food contest, the hosts point to the broader medical potential of these findings. By studying how Highveld Mole Rats "block the sensation" of pain, researchers hope to gain insights that could eventually help humans. Understanding these biological pathways could lead to better methods for managing pain in medical settings, such as during surgery or recovery, by potentially tricking the human brain into ignoring certain types of discomfort.

Conclusion

The episode serves as a reminder of the wonders of evolution and the complexity of the nervous system. While Grandma G-Force may have been dethroned by a mole rat, the scientific discovery behind Harold’s victory offers a significant "wow" moment. As Mindy and Guy Raz conclude, nature often holds the keys to solving complex human problems, even if those keys are found in the most unlikely places—like the brain of a small, wasabi-munching mole rat.

🎯Key Sentences

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It's going to be a November to remember.
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But for now, let's get on with the show.
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Sheesh, she must be in the shower.
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What's taking you so long?
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That sounds like fun.
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📝Key Phrases

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music to your ears
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get on with the show
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better off
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take off
5
what's taking you so long
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📖 Transcript

Grownups, Wondery Plus subscribers can listen to Wow in the World early and ad-free right now.
Join Wondery Plus in the Wondery app or Wondery Kids Plus on Apple Podcasts.
Hey, Wowzer fans, Mindy here.
And before we start the show, I gotta let you know that this November, with a special new episode featuring our friends at Circle Round and Terrestrials on Radiolab for Kids,
And don't miss when Elmo from Sesame Street stops by Wow in the World to make us all belly laugh on November 24th.
Oh, but that's not all, Reg.

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