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[The Science of Pain: Why Highveld Mole Rats Don't Feel the Burn of Wasabi]-[G-Force Vs. Wasabi: How The Brain Registers Pain]

Wow in the World · B1 · 2019-06-17

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📋 Summary

The Science of Pain: Understanding Wasabi Resistance in Highveld Mole Rats

In a recent episode of Wow in the World, hosts Mindy and Guy Raz explore the fascinating intersection of biology, pain perception, and evolution. Through a lighthearted narrative involving a "Hot Pickle and Pepper Championship," the show dives into the scientific mechanisms behind why certain species, specifically the Highveld mole rat, remain completely unaffected by the intense chemical burn of wasabi.

The Chemistry of Heat: Capsaicin vs. AITC

The competition highlights two distinct types of "heat." The first is the well-known sensation caused by spicy peppers, which contain a chemical called capsaicin. The intensity of this heat is measured using the Scoville heat unit scale. While a standard jalapeño measures around 4,000 Scoville units, the peppers used in professional competitions can reach up to 2 million.

However, the show introduces a different, more deceptive kind of heat: wasabi. Unlike peppers, wasabi does not rely on capsaicin. Instead, it contains a chemical compound known as allyl isothiocyanate (AITC). As Guy Raz explains, AITC targets the sinuses and the areas above the eyebrows rather than the tongue. It produces a sensation that can make one's head feel like it is "going to explode," yet it operates through entirely different chemical pathways than chili peppers.

The Evolutionary Marvel: Highveld Mole Rats

The episode centers on a scientific breakthrough by Dr. Gary Lewin of the Max Delbrück Center in Berlin. Dr. Lewin previously discovered that naked mole rats are insensitive to capsaicin because they lack the specific neurons—the cells responsible for passing pain information to the brain—that signal discomfort from peppers.

However, when faced with wasabi (AITC), even the resilient naked mole rat struggles. The true surprise comes in the form of the Highveld mole rat. In the podcast’s narrative, this species manages to consume wasabi without any reaction, dethroning the other competitors. This is backed by real-world science: Dr. Lewin found that Highveld mole rats possess a unique biological "escape hatch" in their neurons. This mechanism allows the AITC chemical to leak out or be blocked before it can transmit a pain signal to the brain.

Why Evolution Favors Pain Resistance

Why would a creature evolve to ignore such a potent chemical? The show explains that Highveld mole rats live underground in environments shared with a species of ant known as natal drop tails. These ants possess a sting that contains a chemical remarkably similar to AITC. Over millions of years, the Highveld mole rat evolved to be resistant to this pain as a survival mechanism against these aggressive ants.

Implications for Human Medicine

Beyond the humor of a mole rat eating wasabi, the podcast touches on the profound medical potential of this discovery. Scientists believe that by understanding how the Highveld mole rat’s neurons successfully block pain sensations, researchers might eventually develop new ways to help humans manage pain. This could be particularly revolutionary for patients undergoing surgery or those suffering from chronic pain conditions, offering a way to "trick" the human nervous system into not noticing certain types of discomfort.

Ultimately, the episode serves as a reminder that the natural world holds incredible secrets. Whether it is the biological evolution of a small rodent or the complex chemistry of the spices on our dinner plates, there is always more to learn about the world around us—or as the hosts put it, there is always more to "wow" about.

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📖 Transcript

Grownups, Wondery Plus subscribers can listen to Wow in the World early and ad-free right now.
Join Wondery Plus in the Wondery app or Wondery Kids Plus on Apple Podcasts.
Hey, Wowzer fans, Mindy here.
And before we start the show, I gotta let you know that this November, with a special new episode featuring our friends at Circle Round and Terrestrials on Radiolab for Kids,
And don't miss when Elmo from Sesame Street stops by Wow in the World to make us all belly laugh on November 24th.
Oh, but that's not all, Reg.

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